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| Spy Shop South Africa | Durban | Security Surveillance | |
| SQ Garage Doors and Gate Systems | Cape Town | Install and repair garage doors + motors +gates | |
| Squeak n Kleen | Johannesburg | Home and office cleaning, Carpet and upholstery | |
| Squiggle | Johannesburg | At Squiggle we believe in individuality, in giv... | |
| Squire Solutions Recruitment | Gauteng | Recruitment consulting, IT Software Development | |
| SR Communications | Durban | Business Consulting, Business Plans and Funding Sp | |
| Sree Manasa Psychiatric Nursing Home | hospital | ||
| SrsBsns | Johannesburg | Web development | |
| SS Associates | Construction | ||
| SS Enclosures | Pretoria | Electrical Manufacturers | |
| SSC Advisory | Centurion | Socio-economic transformation advisors | |
| Ssda Debt Collections | Johannesburg | Debt Collection | |
| SSQ Exhibitions | Johannesburg | Exhibition Stands, PermaneInteriors, Mall Displays | |
| SSS Marketing Services | Benoni | Services and Telecommunications | |
| sss www | bbbeeee | ||
| St Augustine | Johannesburg | Education | |
| St Catharines Roofing Pros | St. Catharines | St Catharines Roofing Pros | |
| ST Communications | Cape Town | Brainwave Projects 2298cc | |
| St Francis Chronicle | St Francis Bay | Monthly community tabloid | |
| St John's Christian Brothers' College | Cape Town | School | |
| Stab-A-Load | Alberton | Cold Storage/Commercial Doors/Conveyors | |
| Stacey Freight International | Johannesburg | Stacey freight international is a logistics compan | |
| Staff Connection | Germiston | Recruitment | |
| Staff Training | Cape Town | Training | |
| Stage Audio Works | Johannesburg | Audio, Video, Lighting, Rigging & Structures | |
| Stained Design | Johannesburg | Design in general - from A to Z | |
| Stainless Design | Port Elizabeth | Stainless Steel Manufacturing and supply | |
| Stamp Communications | Sandton | PR | Communications | Video Marketing | |
| Stanford Payne Coaching | Stellenbosch | Executive Entrepreneur Business Career Coaching | |
| Stanley Robert Investments (Pty) Ltd | Johannesburg | Property Rentals | |
| Stanton Optical Oak Creek | Optical | ||
| Staplenet systems | Cape Town | No.1 provider for total DSTV, home entertainment | |
| Staples Copy & Print | Sandton | Printing | |
| Star Boi Entertainment | Pretoria | Photography/Graphic Design | |
| Star Trackers | Cape Town | Entertainment | |
| Starbright Solutions | Pretoria | Digital Marketing | |
| STARC | Cape Town | Residential and Commercial building design | |
| Starcloth Solutions | White River | Starcloth & Draping rentals in South Africa | |
| Starlite Aviation Group | Durban | Flights, Training, Maintenance, Operations, Sales | |
| Starlite Media | Port Elizabeth | Event management and Live Entertainment | |
| Staroot Media | Vosloorus | Media Communication | |
| Start a Dairy Business | chennai | Start a Dairy Business | |
| Start-Up Mentors | Cape Town | Startup: Business Coaching, Mentoring and Training | |
| startupAFRICA Media (Pty) Ltd | Johannesburg | Marketing, Radio & TV advertising, Media Planning | |
| Statanalytica | statanalytica | ||
| State OF The ART Projects Gallery | Johannesburg | Film Production, Videography & Photography | |
| StateoftheART Gallery | Cape Town | Contemporary Art Gallery | |
| Station One Design cc | Johannesburg | All Signage, Graphic Printing, Portable Displays | |
| Status Waterproofing | Johannesburg | Waterproofing, Damp Proofing, Roof Repairs, | |
| Status Waterproofing Johannesburg | Houghton Estate | Status Waterproofing Johannesburg | |
| Status Waterproofing Rustenburg | Rustenburg Oos-Einde | Status Waterproofing Rustenburg | |
| Stealth Services | Johannesburg | Web Development | |
| Steam And Valves Specialists | Johannesburg | Steam And Valve Specialists | |
| Steam Cleaning Services | Port Elizabeth | Carpet cleaners, carpet and upholstery cleaning | |
| Steam Easy | Coventry | Carpet cleaning Coventry, Professional carpet clea | |
| Steel & Fibreglass Grating SA | Boksburg | Manufacture fibreglass grating in South Africa | |
| Steel & Pipes for Africa - Cape Town | Cape Town | Supplying steel products | |
| Steele Storage Systems | Cape Town | Shelving, Racking, Bulk Filing Systems | |
| Steelworks Fabrication Services | Blackheath | Fabrication of steel products | |
| Steinser Alliance Group | Sandton | Branding, Mobile Apps, Training, TV Productions | |
| Stella OST to PST Converter | Email Recovery | ||
| Stella-Rose Skin | Cape Town | Children's Skin Care Range | |
| Stellar Radio Networks | Cape Town | Retail Radio Broadcast and Instore Audio Services | |
| Stellenbosch University LaunchLab | Stellenbosch | Startup Programmes, Events | |
| Step Building Supplies | Hardware & building supplies | ||
| Step It Up Camp | Mill Creek | Step It Up Camp | |
| Stephanie Photography | Cape Town | Cape Town Photographer | |
| Stephanie Rouillard | Cape Town | Dietitian | |
| Sterkla | Online business coaching through mobile app | ||
| Sterling Access | Nkangala | Rentals and Sales | |
| Sterling Hospitality | Cape Town | Hotel Resort Management/Development | |
| Stettyn Cellar | Villiersdorp | Wine | |
| StevovoT/A Moniquesplace | Germiston | Comprehensive IT Solutions Delivered Countrywide | |
| Steyns Culinary School | Pretoria | Diploma courses, short courses | |
| Stiltz Home Lifts | Cape Town | Home lifts, home elevators, residential lifts | |
| STIR Digital | Durban | Digital Marketing | |
| Stobac Aircons | Benoni | Air Conditioning Spesialists | |
| Stobel Cape | Cape Town | Warehousing and Transport | |
| Stobel Durban (Pty) Ltd | Durban | Warehousing and Transport | |
| Stobel Johannesburg (Pty) Ltd | Johannesburg | Warehousing and Transport | |
| Stock Counters | Cape Town | Stocktaking | |
| Stock Market | Stock Market | ||
| Stockdale & Leggo | Stockdale & Leggo | ||
| Stoi Business Consultants | Sandton | Enterprise dev, business consulting & project | |
| Stokdirect Virtual Wholesale | FMCG Wholesale & Distribution | ||
| Stoked Surf | Cape Town | Surf Lessons, Surf Guiding, Surf Trips and SUP | |
| Stokvel Academy | Johannesburg | Stokvel | |
| Stone & Gray | Cape Town | 42 Leeukloof Drive | |
| Stone & Grays | Cape Town | Home Decor | |
| Stone Countertops | Roodepoort | granite countertops | |
| Stoned Crystals | Elsternwick | Jewellery & Crystal Shop | |
| Stonehenge River Lodge | Parys | Conference And Accommodation | |
| Stoneshield | Johannesburg | Manufacturer of natural floor sealants | |
| Stoneworks Signage & Print cc | Cape Town | 3D Printing, Graphic Design, Digital Printing | |
| Storage Chief | Brackenfell Cape Town | Storage Chief | |
| StorageBuddy | Self storage company |
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