| Dlphoto Photo Studios | CAPE TOWN | Photography services | |
| Dludlu Brothers | Gauteng | Logistic soluthion | |
| DM Consortium | Kempton PArk | Office Consumables, Stationery & Hygiene | |
| DM Office Solutions | Kempton Park | Stationery and Office consumable Wholesaler | |
| dmg Events | Johannesburg | Exhibitions | |
| DMH Talent Agency | Cape Town | Talent Management/Models/Actors/Singers/Dancers | |
| DMME Translation Services | | Professional translation and editing services | |
| DMV Architecture | Port Elizabeth | Architecture, interior design, project management | |
| DNA Cleaning | Cape Town | Selling of natural cleaning products | |
| DNA Community | Cape Town | Business and Growth Hacking | |
| DNA Healtjh | Johannesburg | Cold Press Juicers and Super Blenders | |
| DNA Studios | Cape Town | film, television, corporate videos & animation | |
| DNA Test | Boulevard Umhlanga | Forensic and Relationship DNA Testing | |
| DNR Auto AND Roadside | paarlshoop | LOCAL AND LONG DISTANCE TOWING. MEDIUM AND HEAVY T | |
| Doan Restoration of MichiganMI | Port Huron | Water damage restoration service | |
| Doctor Debt | Scottburgh | Debt Review | |
| Doctor Fix-It Plumbing, Heating & Electric | Denver | Plumber | |
| Doctortajmel.com | | Mumyaznet | |
| DoDo Safety and Industrial | Johannesburg | Safety Inspections and PPE | |
| DogOnline | Randpark Ridge | DogOnline Exclusive Pet Store | |
| Dolfin SEO | Beaufort | Marketing, SEO, Web Design, Digital Marketing | |
| Doll Communications | Pretoria | Branding and events | |
| Dolsin Business Solutions | Roodepoort | Online Communication & Marketing tools for SME's | |
| Domestic Aid | Ekurhuleni | Direct marketing | |
| Domestic Garage Doors | Boksburg | Garage door repairs, maintenance and service | |
| Domestic Support | | Employer & Domestic Worker Services UIF and more | |
| Domyassignmentpro | | Digital Marketing | |
| Don Media and Branding | Johannesburg | website design | |
| Donald J. Trump Golden Check | New York | Golden Trump Check Reviews | |
| Donaldabram | | Direct Marketing | |
| Doncour Recruitment | Durban | Recruitment | |
| Dong Cai Education | LONDON | Education | |
| Donna Watson Photography | Port Elizabeth | Photography | |
| Donnelly Tool Hire | Hermanus | Donnelly Tool Hire | |
| DONT BLINK | Port Elizabeth | Clothing | |
| Dont Speak Digital | Cape Town | Dont Speak Digital | |
| DonValley Brand Reputation Managers | Cape Town | Corporate/Brand Reputation Management Consultancy | |
| Doodah | Alberton | Consumer Electronics/Components Supplier. | |
| Doom Spray | Johannesburg | Insecticide | |
| Door 2 Door | | Locksimth | |
| Door 6 Entertainment | Cape Town | Corporate Functions, Live Shows and Entertainment | |
| Doors and Drawers The Custom Wood and Steel Co. | Cape Town | Kitchens, Joinery, Steel and custom furniture | |
| Doors Spectrum Entertainment | Johannesburg | | |
| Dorothywilson | | direct marketing | |
| DOT Effect Solutions | Cape Town | IT consulting | |
| Dot Me Media Print | Randburg | Labels | |
| Dot Slash | Pretoria | Web Development Website Design | |
| Dot Web | Uvongo Beach | Web Design | |
| DotActiv | Germiston | Category Management Software/Services | |
| Dotcom Africa | Durban | Advertising and Marketing | |
| Dotcreative Marketing Solutions | Durban | dotCreative Marketing Solutions is a full service | |
| Dotjam | | Multi-channel strategic consultancy | |
| Dotkay Language Solutions | Polokwane | Translation services | |
| Dots Connect Technology | Pretoria | Sell Computer Equipment/ Networking Slotions | |
| Dotsquare Media Agency (Pty) Ltd | Centurion | Branding agency with in-house designers/ printer | |
| DOTZ Interactive | Durban | IT Solution Providers | |
| Double Technology s.r.o. | | Loan comparators around the world | |
| Double-U Design | Pretoria | Below the Line advertising | |
| Double-U-Design | Centurion | Advertising & Design | |
| Doug Ford Signs | | Advertising and Signage | |
| Douglashongkong | | douglashongkong | |
| Dowd Engravers Pezula signage solutions | Cape Town | industrial manufacturing, lasercutting, printing | |
| Down South Towing | Cape Town | 24 hour mechanical and breakdown service | |
| Downtown Creative Agency (Pty) Ltd. | Johannesburg | Graphic Design, Packaging Design, Advertising | |
| Doyze Media | Rustenburg | graphic designer, 3d animation, web developer | |
| DP Print | Roodepoort | Full service printing and finishing | |
| DPI Concepts | Johannesburg | Branding | |
| Dr Alek Nikolic | Cape Town | 33 Piers Road Wynberg Cape Town | |
| Dr Andre De Villiers - Orthodontist | Cape Town | Orthodontist | |
| Dr Bruce Lelala | Sandton | Plastic & Reconstructive Surgery | |
| Dr Candice Mnguni | Johannesburg | Healthcare | |
| Dr Gerald B Kaplan | Johannesburg | Dental | |
| Dr JJ Serfontein | JJS Dentistry Cape Town | Cape Town | Dentistry | |
| Dr Katri du Toit | Pretoria | Homeopathic practitioner | |
| Dr Kay U. Brugge | Cape Town | Life Coaching, Mentoring, Life Strategy | |
| Dr Khali Thenga | Johannesburg | Psychotherapy and market research | |
| Dr Leana van Dyk | Paediatrician | Cape Town | Medical Practice | |
| Dr M Khusal | Sandton | Painless dental work | |
| DR Muhammed A Traditional Healer In South Africa | Johannesburg | health | |
| DR Nachlas | | drnachlasinfo | |
| Dr Natalia Novikova | Cape Town | Gynaecologist | |
| Dr Richard Wayman Chiropractor | Randburg | Chiropractor | |
| Dr Ronel Podde Inc. | Pretoria | Dental Surgeon | |
| Dr S Ranchod | Cape Town, South Africa | Maxillofacial and Oral Surgery | |
| Dr Sizwe Derrick Mthiyane | Richards Bay | Medical Practice | |
| Dr Sunil Thakersee | Cardiologist Cape Town | Cape Town | Medical Practice | |
| Dr Tanja Beeton Audiologist | Cape Town | Audiology | |
| Dr. S. Sibisi | Mabopane Medical Centre | Mabopane | Doctor | |
| Dragon Consulting | Johannesburg | Research Capacity, Research Services | |
| Dragon Pharam SA | | South African distributors of Dragon Pharma sports | |
