| TOLOS VIP SECURITY Pty Ltd | Johannesburg | Security Guards-VIP Shuttles-Event Security | |
| Sam Hospitrain (Pty) LTD | Benoni | Training Business | |
| Social Enterprises Management Accountants | Johannesburg | Small Business Consulting and Accounting | |
| Zania Group | Bloemfontein | Business Development Solutions | |
| SiyaPromo | Springs | Socially impactful African marketing solutions | |
| Silver Cloud Accounting | Cape Town | Accounting, Payroll & Business Advisory Services | |
| Rosy's Event Design and Decor | Cape Town | Events Decor and Design | |
| Viatron Cleaning Services (Pty) Ltd | Cape Town | Cleaning services public, private sector entities | |
| Simplify Recruitment Services | Pretoria | Recruitment of staff | |
| Sandton Taxi Cabs | Sandton | Staff Transport, Airport Transfers,Shuttle Service | |
| True Wealth Solutions | Durban | Financial advisory services | |
| S Packery Chartered Accountants | Nelspruit | Audit Firm | |
| Soil Poisoning Services | Warden | Soil Poisoning Services | |
| UPrint SA | Durban | promotional gift suppliers and digital printing | |
| RSA Catering | Johannesburg | Catering Services, Caterer | |
| Simpson Accounting (Pty) Ltd | Randburg | Accounting Services | |
| TS Translations CC t/a Perfect Language | Johannesburg | Translations | |
| The Best Private Investigator Cape Town | Cape Town | Private Investigations | |
| Tri Wealth | Cape Town | Insurance | |
| Terabyte Website Design Pietermarizburg | Pietermaritzburg | Website Design and Online Marketing | |
| Tweak Group | Johannesburg | Transport | |
| Robot TV | Cape Town | Film and Content Production | |
| Roche Bobois | Cape Town | Leading high end editor of furniture and deco | |
| RocketHost | Johannesburg | Hosting Provider | |
| Rocket Trading | Robertson | Home improvement | |
| Rodel Financial Services | Durban | Bridging Finance | |
| Rolfe Auto Repair Services | Pretoria East | Mechanics | |
| Romaflo Travel | Newcastle | Travel Services. | |
| Roodepoort Tree Felling | | Tree Felling | |
| Rooihuiskraal Geyser Repairs | Pretoria | Plumbing Repairs | |
| Ropelius. Brand and Design | Cape Town | Branding and Packaging Design | |
| Rospa Transport & Services | Benoni | 91 Woburn Avenue,Benoni | |
| Royal Electronics Sales and Services | | Royal Electronics Sales and Services | |
| Royal Hairstyles Training Academy and Salon | Johannesburg | SETA-accredited hairdressing academy | |
| Royal Investigations | Cape Town | Cheating spouse, fraud, trace | |
| Rozewood | Pretoria | Managing agent, Sectional Title Homeowners Ass | |
| Rutech Solutions | Roodepoort | IT Service Solutions and Graphic Design | |
| Ry Cin Group Shuttles Tors and Adventures | Cape Town | Airport shuttle service, Tours & group transport | |
| Ryder Consulting | Benoni | Business Consulting | |
| S.S Engineering Services | | S.S Engineering Services | |
| Safe House Services , . | Worthing | Plumbers | |
| Safe RO Service | | Safe ro service | |
| Safety Connection KZN | Durban | Health and Safety Consulting and Compliance | |
| Sage Legal Services | Johannesburg | Legal and Consulting | |
| Saglotech Web Design | Johannesburg | Web Design | |
| Sai Motors South Africa | Cape Town | Hydraulics Motors | |
| Sakha Isizwe Engineering and Projects | Standerton | Electrical and mechanical mainteance | |
| Sales Hub for Africa | | Sales Solutions and Sales Outsourcing | |
| Saltyfm | Johannesburg | sound hire | |
| Salvagedata Recovery Services Mint Hill | Mint Hill | DATA Recovery Services | |
| Samantha Atrash, Fundraising and CSI | Edenglen | Fundraising, Corporate Social Investment | |
| SA Mobile Drug Testing | Cape Town | Drug and Alcohol Testing, Toxicology, Abuse | |
| Samplex Africa | Johannesburg | Field Sales Merchandising Brand Activations | |
| SANCSERV SECURITY SERVICES | Johannesburg | security services | |
| Sancserv Cleaning Services | Johannesburg | Cleaning Services | |
| Sandilands et al | Bedfordview | Compliance governance Payroll Accounting HR IR | |
| S&S Mechanical Services Inc | | HVAC | |
| SaniTate360 | Cape Town | Cleaning/Sanitizing-office,w/h,toilet,kitchen, etc | |
| Sarah-Rose Décor | Port Elizabeth | Décor | |
| SAstudio | | advertising and media | |
| SA TaG | Johannesburg | Business listing, marketing and advertising | |
| SA Teen Entrepreneur | Cape Town | Cultivate and promote entrepreneurial spirit | |
| Satrim Technologies | Durban | Web Solutions | |
| Saving GraceTutors | Johannesburg | Saving Grace Tutors is a Private Tutoring Company | |
| Savs Decor and Catering | Durban | Catering for all parties, functions, weddings | |
| Scan4U Scanning Services | Modderfontein | Document scanning services and scanning bureau | |
| Weblab | Durban | Web Design, Website Design, Online Marketing, SEO | |
| SEA Hospitality Consultants (Pty) LTD | Port Elizabeth | Hospitality Consultant | |
| SearchMedia | Johannesburg | Online Marketing, SEO Services, App and Web Design | |
| Sebashe consultants and Field marketers | Kempton park | Direct marketing | |
| Seed of Prosperity - Financial Wellness Experts | Johannesburg | Employee financial wellness for peak productivity | |
| Segage Gardens and Landscaping | Bushbuckridge | gardening,lawn mowing, landscaping,grass cutting | |
| Segcom Group | Pinetown | Hardware and Software Support, Solar Systems | |
| Sekunjalo Group | Cape Town | Broadcasting and Media | |
| The Movement Trust | Cape Town | Film & TV Production | |
| SelfieBox | Pretoria | Photo booth hire, GIF and Video booth rentals | |
| Semipoi Online | | Semipoi Online Nonton Film Semi 2020 | |
| Sengikwenzile Supplier Services | Durban | Road Freight Logistics | |
| SeniNhle Occupational Health Services | Pretoria | Asbestos, risk assessment, noise, ergonomics, HCS | |
| SeniNhle Occupational Health Sevices | Pretoria | Occupational health and safety, risk, hygiene | |
| Sentinel Commercial Services Group | Cape Town | Business Sales and Valuations | |
| Sentinels Leak Detection Services | Johannesburg | Leak Detection on property plumbing systems. | |
| SEO Institute | Johannesburg | SEO & Brand Awarness | |
| SEO Traffic | Cape Town | Search Engine Optimization, Local SEO, SEO Package | |
| Septic Tank Cleaning(PumpItUp Liquid Waste) | Midrand | Septic Tank Cleaning/Pumping | |
| Servamus Safety & Security Magazine | Pretoria | Safety/Security Magazine | |
| ServeIT Data | | b2b email list providers | |
| Service Basket | Cape Town | Online Advertising platform | |
| Service First AC Repair | San Antonio | HVAC | |
| ServiceGurus | Cape Town | Skills Development, Training and e-learning | |
| Service Master East Rand Pest Control | | Pest control management | |
| Service Systems | Cape Town | Retail Analytics and Customer Experience | |
| Seta Accreditation Services | Ramsgate | Training Provide Accreditation, Skills Development | |
| Sheshisa Online | Johannesburg | Grocery shopping and delivery services | |
| Shipx | Randburg | Shipx logistics services | |
| Show TV | Johannesburg | Video, Photographic & Graphic Design Company | |
| Shubone Events | johannsburg | wedding and event planning,Hiring services,florist | |
| Shumba Connect | | telecommunications | |
| Shumu Protection Services | Cape Town | Security Guarding | |
