On Monday, World Aids Day, Barbara Hogan is to announce a return to the National Aids plan, dropped under Mr Mbeki's rule, at a stadium event designed to mobilise the nation in the fight against the epidemic.
The high-profile media campaign to raise awareness is planned, including persuading famous people to have themselves tested for HIV.
UK International Development minister Ivan Lewis said it was vital that Ms Hogan succeed in overturning myths about HIV/Aids. He said: "For too long, South Africa has been fighting Aids with its hands tied behind its back.
"Those ties have now been removed and the country has a fantastic opportunity to finally turn the tide in its struggle against this epidemic.
"Barbara Hogan has set a bold and exciting vision on HIV and Aids and that is why the UK is fully committed to working with her as she embarks on this new approach."
There is now a critical window of opportunity before next spring's elections in South Africa.
